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5.10 Hyperammonemia and Encephalopathy Associated with Concomitant Topiramate Use Concomitant administration of topiramate and valproate has been associated with hyperammonemia with or without encephalopathy in patients who have tolerated either drug alone
Other studies in rodents indicate parallel effects for other addictive drugs including nicotine, opioids, and stimulants
DOI: 10.3390/antiox10030364
The studys unique geographical context, conducted in Australia, also adds valuable evidence to the global body of research, providing insights into how these medications may impact dementia risk in different healthcare and population settings
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