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Small lumps at the injection site are common and usually resolve within a few days as the medication absorbs
It mimics the effects of the GLP-1 hormone, which helps to increase insulin secretion, decrease glucagon levels, and slow gastric emptying to improve glycemic control
For patients without diabetes or clinical ASCVD with an estimated 10-year risk of CVD exceeding 10%, consideration of starting a GLP-1 RA carries a Class 2b, Level of Evidence C recommendation to reduce CV risk
In this review, the mechanisms of RE, including injury to intestinal stem cells, damage to the vascular endothelium, reshaped immune microenvironment, and mucosal barrier dysfunction, are discussed
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