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GLP-1 receptor agonists e.g., semaglutide, liraglutide commonly cause gastrointestinal adverse effects such as nausea, vomiting, diarrhea, constipation, and abdominal discomfort, especially during dose escalation, less common risks include pancreatitis, gallbladder disease, and hypoglycemia mainly with insulin sulfonylureas

While the study is still ongoing, control group examinations using diet-induced obese mice have shown improvements in insulin sensitivity

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While it is a monotherapy used to treat type 2 diabetes, the drug has also been hailed for its weight-loss benefit