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6-month duration may not capture full benefit
It can miss: impurities with similar retention times, peptides that do not absorb well at the detector wavelength, and endotoxin contamination, which requires a separate LAL or recombinant factor C assay
In preclinical models, Dihexa demonstrated superior pharmacokinetic properties, including good oral activity and effective BBB penetration, along with enhanced metabolic stability with a half-life of 335.5 minutes
doi: 10.1016/j.xcrm.2024.101476 128 RomeroSPellaRZorrillaIBerroPEscuderoFPrezYet al
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