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For instance, disruption of circadian rhythms by repeated advances in the light-dark schedule in rodent models consistently altered expression of core clock genes such as Per2 and Bmal1, leading to impaired immune function, including reduced NK cell cytotoxicity and decreased expression of cytolytic factors like IFN, perforin, and granzyme B

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The expression of various genes encoding complex I-driving proteins, such as NDUFC1, NDUFB4, NDUFB10, NDUFB11, NDUFA12, NDUFA13, NDUFS7, NDUFS2, and NDUFA7 , showed the most pronounced reduction in IC-B cells in ABMR ( Figure 4D )