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Although conceptually distinct, in practice, many biomarkers used in trials perform both roles simultaneously
HGH (recombinant GH) supplies exogenous GH directly (bypassing hypothalamic/pituitary control), producing higher circulating GH levels but without restoring physiological pulsatility
Menkes disease involves copper absorption problems
If I see someone in a clinic and they've been living with obesity for 15 years versus someone for two years, I kind of render the same treatments
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