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BMC Cardiovasc Disord, 2014, 14, 88
HPG axis central effects: hypothalamus and pituitary Evidence on the potential neuroendocrine actions of GLP-1 on HPG axis was provided by an in vitro study in a rodent hypothalamic neuronal cell line (GT1-7) that reported a dose-dependent stimulating effect of GLP-1 on GnRH release, in association with a prompt increase in the plasma LH levels following the intracerebroventricular injection of GLP-1 in male rats [34]
This inherent protective quality is not confined to a single organ system but rather exerts a stabilizing influence across various tissues, providing the mechanistic foundation for its dual action in both the gastrointestinal tract and the central nervous system
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