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While the latter are truly innovative, the accessibility of monoclonal antibodies poses specific challenges in LMICs despite recent progress

Layering on requirements for optimal pharmacological profiles and drug-like properties to support oral dosing adds another level of complexity. But acording to Terry Kenakin, a former GSK drug developer now at the University of North Carolina-Chapel Hill in the US, we are in what I call a renaissance in terms of finding compounds that modify the function of these [GPCR receptors]

Ann Rheum Dis 76(9):15501558

It is unclear whether the delayed cell growth after GPNA treatment is caused by ASCT2 inhibition