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The ferroptosis-sensitive cellular transferrin receptor 1 (TFR1) can transports Fe 3+ into cells for reduction to Fe 2+ , which is stored in the intracellular unstable iron pool in the form of an iron storage protein complex consisting of a ferritin light chain polypeptide, and a ferritin heavy chain polypeptide in the presence of divalent metal ion transport protein 1 (DMT1)
Despite being one of the original nitric oxide precursors, L-arginine maintained a loyal following who found it more effective than newer alternatives
menstrual regularity improved in 60% of participants despite no direct hormonal effects
We have seen in the data that even without significant blood sugar lowering, there seemed to be some sort of anti-inflammatory effects, so we dont really know the mechanism yet, but some people do microdose it for autoimmunity. Shafer himself has made the switch to retatrutide after taking other GLP medications and plateauing
