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Factors Indicating Need for Dose Escalation Increase doses when minimal subjective improvements after 3-4 weeks at current dose, IGF-1 levels show minimal or no meaningful increase from baseline after an adequate trial period (e.g., 812 weeks), good tolerance without significant side effects suggesting room for higher dosing, and treatment goals require more aggressive approach than current dose provides
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In a statement, Novo Nordisk, maker of the GLP-1 drug semaglutide, noted, For Wegovy specifically, animal studies suggest there may be risks to the fetus, and weight loss during pregnancy offers no benefit and may cause harm
While some people might lose weight over time, the fact that the FDA hasnt approved compounded semaglutide raises concerns about its quality and safety, including risks like contamination or incorrect dosages
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