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The amidated C-terminal residue differs across CT-family peptides and this residue forms the only direct contact with RAMPs in previously reported AMYR complexes 15,16
DSIP readily crosses the blood-brain barrier to exert central effects [7] and may enhance inhibitory neuronal activity or modulate sleep-regulating brain regions
This remains an emerging application and should be discussed carefully with your provider, but for patients who have plateaued with conventional rehabilitation, Synapse may offer an additional pathway
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