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However, approximately 510% of patients discontinue treatment due to persistent gastrointestinal intolerance

Semaglutide activates the GLP-1 receptor exclusively, whereas tirzepatide activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptorsmaking it a dual-action or 'GIP/GLP-1 agonist.' This dual targeting amplifies insulin secretion and may produce greater weight reduction in certain individuals

Hypertension and metabolic syndrome together lead to more cases of left ventricular hypertrophy, microalbuminuria, increased intima-media thickness, and hypertensive retinopathy (115)