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The participants in the bariatric surgery study recruited at Bellvitge University Hospital were enrolled in a registered clinical trial (ISRCTN14104758, and the primary outcomes have been published in Casajoana et al

This may cause nausea in the early weeks or after increasing the dose

After three basal measurements, cells were permeabilized by injection of saponin (1 g/mL, Sigma S4521), together with 1 mM ADP (Sigma 01905) and the following respiratory complex substrates: CI, pyruvate/malate (5 mM/2.5 mM)

Semaglutide and tirzepatide both reduce appetite and slow gastric emptying, but they differ in dosing, clinical weight loss averages, and side effect profiles