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Cross-compound receptor-occupancy percentages are deliberately not compared here: occupancy (pRO) is a modeled inference, not a measurement, and Willard 2020 cautions that "calculating pRO values has caveats." These EC50s measure functional potency, not binding affinity

This is due to wide variations in absorption rates

For example, long-term use of oral contraceptives may lower levels of Vitamin B2 (riboflavin) , while some diabetes and epilepsy drugs affect Vitamin B12 (cobalamin) levels