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This is a loading dose designed to introduce the medication to your system

These conditions are extremely common, particularly in women, and many patients safely use GLP-1 medications while on thyroid hormone replacement

No clinically relevant difference in the pharmacokinetics of TRESIBA was identified in a study comparing healthy subjects and subjects with kidney impairment including subjects with end stage kidney disease [see Clinical Pharmacology (12.3)]

If you are currently in a weight loss program and want to discuss whether the higher dose is appropriate for your situation, bring it up at your next follow-up appointment