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Last Published 08.01.2026 Effective Date: 08.01.2026 This policy addresses the use of Tzield (teplizumab-mzwv) to delay the onset of stage 3 type 1 diabetes

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications that mimic the action of the naturally occurring GLP-1 hormone

Elevated levels of systemic or localized IL-6 have been identified in various autoimmune diseases, including rheumatoid arthritis [61, 62], systemic juvenile chronic arthritis, osteoporosis, and psoriasis [63]

They also apply to people with a BMI of 27 or higher when health conditions like high blood pressure, type 2 diabetes, or sleep apnea are present