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When adverse effects occurred, they were typically mild and transient, with the most common being mild to moderate headaches (similar frequency to placebo groups), minor injection site reactions (redness, slight swelling), and gastrointestinal effects at higher oral doses (nausea, diarrhea)
Swelling of the face, lips or throat, widespread rash, or difficulty breathing, which can signal a rare allergic reaction and is a medical emergency
The implications of these changes for human health remain unclear, but it is an active research area
NNMT Biology, Selectivity, and Off-Target Interpretation NNMT, or nicotinamide N-methyltransferase, catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine as the methyl donor, producing N1-methylnicotinamide and S-adenosyl-L-homocysteine
