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16 SIRT1 is broadly expressed in metabolically active tissues 17 and regulates lipid metabolism, 18 mitochondrial maintenance, ROS clearance, autophagy, and immune balance by deacetylating key transcriptional regulators, including peroxisome proliferator-activated receptor gamma coactivator 1- (PGC-1), Forkhead Box O (FOXO), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and p53
Molecules , 24 (10), 19061909
H.GreenamyreT
View on PubMed [PubMed] Systematic review: the safety and efficacy of growth hormone in the healthy elderly (Ann Intern Med, 2007) Systematic review of 31 randomized controlled trials of GH administration in healthy elderly subjects
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