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These medications are contraindicated in patients with: Personal history of medullary thyroid carcinoma Family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) For patients with standard hypothyroidism (typically autoimmune thyroiditis or post-ablation), these contraindications do not apply

For instance, patients may experience symptoms related to liver disease (such as jaundice, abdominal swelling, or fatigue), haematological disorders (including unexplained bruising, night sweats, or weight loss), or kidney dysfunction (such as reduced urine output or swelling)

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