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Targeting lipid metabolic pathways through nutritional modification or adjunctive therapies may complement existing pharmacological and psychosocial treatments, particularly for disorders characterized by metabolic and inflammatory dysregulation
Moreover, the high omega-6 fatty acid content typical of UPFs promotes the formation of proinflammatory eicosanoids, further exacerbating metabolic and inflammatory imbalances (46)
Meanwhile, a post-hoc analysis of the STEP 1 and STEP 4 trials showed that semaglutide 2.4 mg was associated with an approximately 60% reduction of the 10-years risk of T2D according to the Cardiometabolic Disease Staging (CMDS) calculator, regardless of patients baseline glycemic status 74
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