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These medications should only be used under the supervision of a licensed healthcare provider
The anti-inflammatory mechanisms appear to be independent of weight loss or glycemic improvement, suggesting direct immunomodulatory properties
As the field advances, humanized preclinical systems that allow drug evaluation against human targetssuch as GCGR/GIPR/GLP1R humanized mouse modelswill play a pivotal role in bridging the gap between mechanistic discovery and clinical translation
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