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Finally, since endogenous GLP-1 is involved in the regulation of energy metabolism both in the periphery as well as in the brain, compounds acting as GLP-1R agonists can also normalize mitochondrial function, which also appears to be repeatedly disrupted in the depressive brain and thus possibly exacerbate neuroprotective effects, e.g
doi: 10.1038/nrc3038 11 Vander HeidenMGCantleyLCThompsonCB
For a lifter, the proposed benefit is keeping that insulin-sensitive state intact deeper into a surplus, so the partitioning ratio stays friendlier for longer
Effectiveness and safety of semaglutide for weight loss in patients with inflammatory bowel disease and obesity
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