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While the candidate achieved pharmacokinetic objectives, the program was discontinued due to a single case of potential liver injury among over 1,400 trial participants
The risk seems higher in people who take the medicine for weight loss or fatty liver disease
In a final volume of 1 mL, 650 L neutralized supernatant, 330 L of 100 mM sodium dihydrogen phosphate buffer (pH 7.0), and 20 L freshly prepared 0.5 M N-acetyl-L-cysteine were added and incubated for 10 min, after which the optical density was recorded at 288 nm
May support fat utilization during physical activity
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