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Timeline Recommendations Before Trying to Conceive Most reproductive endocrinologists recommend stopping semaglutide at least 8 to 12 weeks before attempting pregnancy
In this 52-week trial of 1,698 people with type 2 diabetes whose blood sugar wasn't adequately controlled on Metformin, orforglipron outperformed oral semaglutide on every primary and secondary endpoint, including A1C reduction and weight loss, with improvements visible as early as four weeks
However, the authors emphasize the need for longer-term studies and trials focused specifically on individuals with binge eating disorder to better understand the full benefits and potential risks of these medications
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