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Thereby, they exert multi-link modulation on the complex pathological network of migraine, which stands in sharp contrast to existing mainstream single-target or highly specific targeted drugs

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Unlike the other DGK which phosphorylate DAG harboring a variety of different fatty acids on the sn -1 and sn -2 positions of the glycerol backbone, DGK epsilon exhibits a preference for DAG containing stearic acid at the sn -1 position and arachidonic acid at the sn -2 position: 1-stearoyl-2-arachidonoylglycerol

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