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10.1002/brb3.1726 101 WangX
The PANK1 gene is located on chromosome 10q23.31 and is composed of 11 exons that generate three alternatively spliced mRNAs each of which encode unique isoforms of the enzyme
10.1074/jbc.M005136200
Increase in intracellular cholesterol content and storage depends on activation of PI3K-Akt-mediated stimulation of SREBP pathway [31], which induces de novo synthesis of sterol or preserves the LDLR-mediated cellular uptake [32, 33]
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