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Health Tool Theres a stark difference between taking GLP-1s for disease management and seeing your running improve as a resultand taking GLP-1s expressly to shave a few minutes off your mile time, experts say

10.1038/228075b0 325

It declines with age, and lower NAD+ is associated with slower metabolism and the changes we lump together as getting older. NNMT, meanwhile, consumes the raw materials your body uses to make NAD+ and in fat tissue, NNMT is often overexpressed, which can drag NAD+ down right where you least want a sluggish metabolism