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Exenatide, the first GLP-1RA approved in 2005, demonstrated clinical efficacy but its low homology with human GLP-1 and gastrointestinal side effects restricted widespread use (Muttenthaler et al., 2021)
Participants receiving the maximum tolerated dose of Zepbound, combined with diet and exercise, experienced an average body weight loss exceeding 20% over 36 weeks, with sustained and additional weight loss observed in ongoing treatment
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