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Decreased methylation of the mitochondrial D-loop region in late-onset alzheimer's disease

For implantable medical devices such as cardiac pacemakers and neural stimulators, traditional batteries suffer from limited service life and the need for periodic surgical replacement, which not only increases patient risk and medical burden but also restricts the long-term operation of the device

Part of each tissue was fixed in 4% paraformaldehyde for morphological examination, and the rest was frozen in liquid nitrogen and preserved at -80 for later experiments