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Due to the diversity of natural products and their derivatives, we categorised them into three groups based on their mechanisms of action: regulation of the proliferation and differentiation of McSCs, promotion of melanin synthesis, and regulation and transport of melanosome
Unlike GPx1GPx4, GPx5 does not contain selenocysteine but contains cysteine residues in the active site, and GPx5 does not exhibit typical dismutation activity toward substrates such as H 2 O 2 (Taylor et al
Detailed forest plots for all secondary outcomes, subgroup analysis and ITCA 650 sensitivity analysis are included in Supplementary Appendix D, except pooled analysis of cardiovascular mortality where this is included in Fig
10.1038/mp.2016.168 60 FryeR
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