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Starting Dose and Gradual Dose Adjustment Management is typically initiated at a lower dose and gradually increased to minimise gastrointestinal side effects and improve tolerability, as directed by the doctor

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The M1 phenotype, stimulated by lipopolysaccharide (LPS) and interferon- (IFN-), was used as a positive control, whereas the M2 phenotype, induced by interleukin-4 (IL-4), functioned as a negative control