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doi:10.1001/jama.2023.24539 45

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Effect of Combination Therapy on Metabolic Outcomes Based on a 2019 meta-analysis of seven randomised controlled trials (1,913 participants) with a primary duration ranging from 12 to 30 weeks, co-administration of SGLT-2 inhibitors and GLP-1 receptor agonists had a less than additive effect on HbA 1c and body weight and an additive reduction in systolic blood pressure compared with each monocomponent without increasing risk of hypoglycaemia [5]

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V., Javadov, S., & Sommer, N

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