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The dynamic regulation of the AKT signaling pathway holds significant pathophysiological relevance in neurodegenerative diseases, as its activity state influences neuronal survival and resistance to proteotoxic stress through multiple mechanisms

doi: 10.3389/fcimb.2025.1662442 Received 09 July 2025 Accepted 18 August 2025 Published 25 September 2025 Volume 15 - 2025 Edited by Yuanwei Zhang, Nanjing Normal University, China Reviewed by Estela Ruiz-Baca, Jurez University of the State of Durango, Mexico Antonio Vitiello, Ministry of Health, Rome, Italy Hu Pengjie, Chinese Academy of Sciences (CAS), China Updates Copyright 2025 Li, Liu, Jiang, Yang, Ni, Zhang and Tan

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