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Blood chemistry panels showed no hepatotoxicity (ALT, AST, bilirubin all within normal limits), no nephrotoxicity (creatinine, BUN unchanged), and no hematologic changes
For 10mg vials referenced in longer protocols or higher-dose escalation 2mL is also commonly cited and yields a higher concentration that keeps injection volumes manageable at 8-12mg doses
A direct head-to-head, the SURMOUNT-5 trial (released 2025), confirmed tirzepatide outperformed semaglutide for weight loss in adults with obesity without diabetes
Do not stop suddenly: discuss significant mood changes with a clinician before changing treatment
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