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Some potential causes of dark inner thighs include: dry skin too much sun exposure chafing from the thighs rubbing together while walking or exercising skin pigment conditions, such as acanthosis nigricans use of certain medications Because some of the potential causes of dark inner thighs are conditions that require treatment, a person should speak to a doctor if they are unsure what the cause is

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Upregulation of CD73 with IFN- has shown the effect of preventing vascular leakage and inhibiting leukocyte recruitment ( Geoff et al