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Previous studies investigating the limitations of conventional AUD treatment highlight that the primary barrier to pharmacological efficacy is the need for intensive behavioral engagement, which has been frequently observed to hinder long-term adherence
LaBarge, S., Migdal, C
EBI is a major determinant of clinical prognosis, driven by multiple mechanisms including cerebral metabolic distress and oxidative stress, CSDs, neuro-inflammation, microvascular dysfunction, BBB disruption, cerebral edema, and cellular apoptosis
Even amylin receptor agonists are entering the conversation as complementary or alternative approaches
