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The combination results in three convergent signals: reduced caloric intake (GLP-1/GIP appetite suppression), improved insulin sensitivity (GIP/GLP-1 pancreatic effects), and elevated calorie burn (glucagon thermogenesis)
Regular, moderate physical activity improves overall muscle conditioning and may reduce cramping frequency
Comparative effects of GLP-1 and GLP-2 on beta-cell function, glucose homeostasis and appetite regulation
In particular, interventions using apps as tools to support DSMES have been shown to have an impact on outcomes [34]
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