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And about 90% of blood lead locates within red blood cells (RBC), which binds the cysteine-rich zinc-binding site of -aminolevulinic acid dehydratase (ALAD) (Mani et al

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What the new mechanism is: GLP-1 : appetite regulation, improved glucose control GIP : incretin effects that may augment metabolic benefits Glucagon receptor activity : potentially influences energy expenditure and fat metabolism (while requiring careful balancing of tolerability and metabolic effects) What results look like (so far): Phase 2 (48 weeks) published in NEJM showed substantial mean weight reductions (with higher doses showing very large effects)