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It has demonstrated significant effects on collagen synthesis and angiogenesis
In the phase 2 NEJM 2023 trial, the net glycaemic effect of retatrutide was favourable improvements in fasting glucose and insulin resistance markers were observed suggesting that the insulin-stimulating effects of GLP-1R and GIPR agonism counterbalanced any glucose-raising tendency from glucagon receptor activation
GCGR/GLP-1R agonist: OR: 0.23, 95%CI: 0.070.75, P = 0.02
This shift has the potential to expand patient access, alter treatment pathways, and introduce new dynamics to how weight loss drugs are marketed
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