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4.4 Neonatal hypoxicischemic encephalopathy The pathophysiology of HIE involves hypoxicischemic injury, characterized by perturbations in mitochondrial dynamics and the inhibition of critical energy-producing pathways, including oxidative phosphorylation and fatty acid -oxidation (54)
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KLOW peptide is primarily administered subcutaneously in preclinical research due to predictable absorption kinetics and ease of technique, but some models investigate intraperitoneal (IP) or intramuscular (IM) routes for specific experimental objectives
This increases the oxidative burden in the body because of the excessive amounts of oxidized glutathione waiting to be recharged by antioxidants
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