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Hydrogen sulfide (H 2 S) metabolism in mitochondria and its regulatory role in energy production

MOTS-c regulates metabolic homeostasis Lee C et al

demonstrated that treatment of AR mice with skullcapflavone II reduced eosinophil levels, and PAS + cells and mast cells in the nasal tissue also reduced IgE and IgG1 levels in serum but had no significant effect on IgG2 levels, as well as reduced TNF-, IL-4, IL-13, and GATA-3 levels and increased IL-12 levels in the nasal lavage fluid and lung tissue, but had no significant effect on IL-10 and IFN-levels

Severe adverse events have not been a pattern in community usage, but human safety data is limited to a few pilot studies