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A single binge-drinking model developed by Carson and Stephen (46 g/kg, perfusion) can simulate blood alcohol levels, behavioral effects, and physiological changes in human binge drinkers and has been widely used (Carson and Pruett, 1996
It stimulates the release of insulin from the pancreas in a glucose-dependent manner (meaning it only releases insulin when blood sugar is high, reducing the risk of hypoglycemia) and suppresses the release of glucagon, a hormone that raises blood sugar
European Journal of Pharmacoly 2002
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