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While Metformin improves insulin sensitivity and helps control appetite, GLP-1 medications (like semaglutide or tirzepatide) slow digestion and enhance feelings of fullness
doi: 10.1007/s00535-021-01796-x 40 TripathiA.DebeliusJ.BrennerD
Increasing skeletal muscle carnitine content in older individuals increases whole-body fat oxidation during moderate-intensity exercise
Without adequate protein, up to 50% of weight lost can be muscle rather than fat, slowing metabolism and reducing long-term success
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