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Its stability depends on the metal staying coordinated to the tripeptide, which makes it sensitive to pH, since the deprotonated amide nitrogen that helps hold the copper is pH-dependent, and outright incompatible with two whole classes of common additive
The combination leads to endothelial dysfunction, cholesterol deposition, inflammation, and finally, calcification.[ref] Oxidized phospholipids are primarily polyunsaturated fatty acids that are oxidized due to ROS, infections, or apoptosis
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Understanding this process helps patients navigate the system appropriately
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