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and indirectly, as the essential co-substrate for glutathione peroxidase (GPx) and glutathione S-transferase (GST) enzymes that detoxify hydrogen peroxide, lipid peroxides, and electrophilic compounds

Specific populations requiring enhanced surveillance include: Patients on long-term metformin (test if deficiency is suspected

Common early side effects include mild nausea, reduced appetite (the intended effect), and occasional constipation or diarrhea

This precision-wellness framework allows you and your provider to anticipate potential interactions, choose the safest pain reliever class, and adjust your semaglutide regimen if gastrointestinal side effects become a barrier to treatment success