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Many patients tolerate metformin well, but gastrointestinal side effectsincluding nausea, bloating, and diarrheaoccur in 1530% of users and can offset any weight loss benefits
Dual agonist (Tirzepatide): Mentioned earlier, tirzepatide (Lilly) is a single peptide that activates both the GLP-1 and GIP (Glucose-dependent Insulinotropic Polypeptide) receptors
Understanding each one gives you a clear path to addressing them
Cryo-EM maps have been deposited in the Electron Microscopy Data Bank under the following accession codes: for the CagriCTRG s complex, EMD-64557 (raw map), EMD-64558 (receptor-focused refinement map), and EMD-64560 (composite map)
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