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Risk-Benefit Assessment : The potential benefits must be carefully weighed against known and unknown risks, particularly given the limited long-term safety data in adolescents
Enhanced expression of GSH metabolism enzymes including glutathione peroxidases, gamma-glutamyl cysteinyl synthetase (gamma-GCS), glutathione S-transferases (GST), and ABC-family membrane transport proteins including the multidrug resistance-associated protein (MRP) were all documented to play prominent roles in cellular resistance to oxidative stress
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Furthermore, studies show that in 67% of cases the symptoms remain into adulthood (Ayano et al., 2023
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