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The trade-off is a lower per-capsule dose (Thornes is 175 mg per capsule, compared to 500 mg in standard capsules)
Reviewing the Certificate of Analysis, confirming HPLC and LC-MS testing, and maintaining proper storage conditions can significantly reduce unnecessary variability between experiments
Source: Jastreboff AM et al., NEJM 2023, supplementary methods
However, other authors [80] have shown that the acute pharmacological activation or inhibition of AMPK had no effect on glucose sensing in VMH GE neurons
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