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The most commonly reported adverse effects of tirzepatide are gastrointestinal in nature, occurring in a substantial proportion of patients during clinical trials
One of the most reassuring aspects of semaglutides safety profile is that the vast majority of side effects are mild to moderate in severity and do not require treatment discontinuation
SCFAs, particularly butyrate, could trigger the secretion of incretin hormone glucagon-like peptide 1 (GLP-1), and the beneficial effects are thought to be elicited via SCFA receptors Ffar2 and Ffar3 13,14,15,16
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