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Phase 3 trials of tirzepatide did not exclude participants taking antioxidant supplements, and subgroup analyses showed no difference in adverse events or efficacy between supplement users and non-users
Limitations of Current Evidence Several significant limitations in the current evidence base warrant acknowledgment: Population Diversity : Most major trials have been conducted in predominantly white, well-resourced populations, potentially limiting generalizability to more diverse demographic groups where obesity prevalence is often highest
Since semaglutide is a protein-based hormone mimic that does not typically pose a risk to the patients receiving plasma-derived therapies, it is not flagged as a deferral medication
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